陈扬

个人简介

2025-至今 北京大学医药卫生分析中心（副主任）

2024-至今 副研究员（Tenure track）：北京大学临床医学高等研究院精准医疗多组学中心（院长助理）

2018—2023  副研究员（Tenure track）：精准医疗多组学中心／基础医学院

2016—2018 副研究员：清华大学生命科学学院

2014—2016 助理研究员：清华大学生命科学学院

2012—2014 博士后：清华大学生命科学学院（合作导师：俞立）

2008—2012 博士：北京大学医学部基础医学专业（美国国立卫生研究院）（导师：柯杨、Matthias Machner）

2004—2008 本科：北京大学医学部基础医学专业

技术领域：

主要研究方向为细胞器生物学发生和基于质谱的蛋白组学方法开发和应用。主要关注外泌体、新细胞结构迁移体等结构发生、物质分选运输等分子细胞生物学机制。应用蛋白质谱技术大规模地发掘基于疾病问题和临床队列的生物标志物，探索疾病发生规律。

代表性成果：

1.Peiyao Fan*, Rui Ji, Yiling Wen, Yaping Dang, Yong Li, Xiaojie Yan, Murong Li, Qiaoxia Zheng, Yifan Ge, Pengli Zheng, Yang Chen#. Contact-Dependent Incorporation of Endoplasmic Reticulum into Retraction Fiber and Migrasomes. Journal of Cell Biology, 2025 Dec 1;224(12) (Cover story).

2. Yiling Wen*, Yong Li*, Jiayi Chen*, Dianxing Liu, Yuan Chao Li, Ying Li, Haohao Tang, Peizhen Gao, Wenmin Tian#, Ning Shen#, Yang Chen#. Toward a comprehensive map of Rab-medated cargoo transport to migrasomes. Science China Life Sciences, online before print.

3. Yuxing Huang*, Xiaojie Yan*, Xing Liu*, Congcong Ji, Wenmin Tian, Haohao Tang, Yong Li, Yiling Wen, Peiyao Fan, Hongli Wang, Cankun Xi, Zhongtian Li, Tian Lu, Fuping You#, Xin Yin#, Yang Chen#. Migrion, a Migrasome-mediated unit for intercellular viral transmission. Science Bulletin, 2025 Aug 23:S2095-9273(25)00870-9.

4. Rui Ji*, Hongli Wang*, Xia Zheng, Dongxue Shi, Wenmin Tian, Peizhen Gao, Yong Li, Yiling Wen, Jianjun Wang, Zhang Liu#, Catherine C. L. Wong#, and Yang Chen#. Tetraspanin 4 Mediates Cholesterol-Dependent Exosome Membrane Protection from Cryodamage. Nano Letters. Epub 2025 May 19 (Cover story)

5. Yong Li*, Yiling Wen*, Ying Li, Xinyi Tan, Shuaixin Gao, Peiyao Fan, Wenmin Tian, Catherine CL Wong#, Yang Chen#. Rab10-CAV1 mediated intraluminal vesicles transport to migrasomes. PNAS. 2024 Jul 23;121(30);

6. Wenmin Tian*, DongXue Shi*, Yinmei Zhang*, Hongli Wang, Haohao Tang, Zhongyu Han, Catherine CL Wong, Liyan Cui#, Jiajia Zheng#, Yang Chen#. Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of large and small circulating extracellular vesicle enriched fraction. Communications Biology. 2024 Jan 15;7(1):99.  

7. Wenmin Tian*, Delin Li*, Nan Zhang*, Guijie Bai, Kai Yuan, Haixia Xiao, Feng Gao, Yang Chen#, Catherine C L Wong#, George Fu Gao#. O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an "O-Follow-N" rule. Cell Research. 2021 Oct;31(10):1123-1125.

8. Wenmin Tian*, Nan Zhang*, Ronghua Jin*, Yingmei Feng*, Siyuan Wang*, Shuaixin Gao, Ruqin Gao, Guizhen Wu, Wenjie Tan*, Yang Chen#, George, Fu Gao#, and Catherine CL Wong#. Immune suppression in the early stage of COVID-19 disease. Nature Communications. 2020, 11(1):5859.